Steven Boyce, PhD, serves currently as Professor in the Department of Surgery at the University of Cincinnati College of Medicine, and as Senior Investigator in the Research Department of the Shriners Hospitals for Children – Cincinnati. He trained in the Department of Molecular, Cellular and Developmental Biology at the University of Colorado, and spent his post-doctoral years in the Department of Surgery at the University of California San Diego. With interests and expertise in engineering of model systems for anatomy and physiology of human skin, Dr. Boyce has designed, characterized and tested engineered skin substitutes consisting of autologous human skin cells and degradable biopolymer scaffolds for closure of severe burns, reconstructive surgery, chronic wounds. Continuing investigations with advanced models of engineered skin are focused on restoration of cutaneous pigmentation, and regeneration of hair and glands after grafting of full-thickness wounds.
Education and Training:
BA: 1974, Biological Sciences, University of Colorado at Boulder
PhD: 1984, Molecular, Cellular & Developmental Biology; University of Colorado at Boulder
Post-doctoral: 1985-1988, Tissue engineering and translational research; Surgery, University of California San Diego
Awards and Honors:
- Macy Scholarship at Columbia University College of Physicians and Surgeons; Physiology and Pathology for Cell Biologists; June-August, 1982.
- Graduate Research Assistantship; US Army Research and Development Command; March‑ October, 1983.
- Faculty Achievement Award; University of Cincinnati; November, 1996.
- Health Care Heroes, Innovator Award; Cincinnati Business Courier; Cincinnati, OH; Feb, 1998.
- Established Investigator Award; Society for In Vitro Biology; Las Vegas, NV; June, 1998.
- Clinical Research Award; American Burn Association; Orlando, FL; March, 1999.
- Seventh most cited first-author in the dermatology literature, 1982-1996. (Arch Dermatol 135:299-302, 1999.)
- Established Entrepreneur Award; University of Cincinnati; May, 2006.
- Three of the top 100 citations in the burn literature from 1955-2011. (J Burn Care Res 35:176-185, 2014.)
- Harvey Stuart Allen Award for Distinguished Service; American Burn Association; Chicago, IL; April, 2015.
Publications (selected from 140 original articles; 215 abstracts; 19 patents; and 18 book chapters):
- Boyce ST and RG Ham. Calcium‑regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum free serial culture. J Invest Dermatol 81, supplement 1:33S‑40S.
- Hansbrough JF, ST Boyce, ML Cooper and TJ Foreman. Burn wound closure with cultured human keratinocytes and fibroblasts attached to a collagen-GAG substrate. J Amer Med Assn 262:2125-2130.
- Boyce ST, D Greenhalgh, RJ Kagan, T Housinger, M Rieman, C Childress and GD Warden. Skin anatomy and antigen expression after burn wound closure with composite grafts of cultured skin cells and biopolymers. Plast Reconstr Surg 91(4):632-641.
- Boyce ST, MJ Goretsky, DG Greenhalgh, RJ Kagan, MT Rieman, and GD Warden. Comparative assessment of cultured skin substitutes and native skin autograft for treatment of full-thickness burns. Annals of Surgery 222(6):743-752.
- Boyce ST, RJ Kagan, NA Meyer, KP Yakuboff, and GD Warden. The 1999 Clinical Research Award. Cultured skin substitutes combined with Integra Artificial Skin to replace native skin autograft and allograft for the closure of excised, full-thickness burns. J Burn Care Rehabil 20:453-461.
- Passaretti D, D Billmire, R Kagan, J Corcoran, and S Boyce. Autologous cultured skin substitutes conserve donor skin autograft in elective treatment of giant congenital melanocytic nevus. Plast Reconstr Surg 114(6):1523-1528.
- Boyce ST, RJ Kagan, DG Greenhalgh, KP Yakuboff, P Warner, T Palmieri and GD Warden. Cultured skin substitutes reduce requirements for harvesting of skin autograft for closure of excised, full-thickness burns. J Trauma 60(4):821-829.
- Chavez-Munoz C, R Hartwell, E Rahmani-Neishabour, F Forouzandeh, RB Jalili, M Jafarnejad, ST Boyce, and A Ghahary. Application of an Indoleamine 2,3-Dioxygenase (IDO) expressing skin substitute improves scar formation in a fibrotic animal model. J Invest Dermatol 132(5):1501-1505. PMID: 22297642.
- Supp DM, JM Hahn, K Glaser, KL McFarland, and ST Boyce. 2012. Differential contributions of deep and superficial keloid fibroblasts revealed using a novel in vivo model of keloid scar. Plast Reconstruct Surg 129(6):1259-71. PMID: 22634643.
- Supp DM, K Glaser, JM Hahn, KL McFarland, ST Boyce. Abnormal responses of keloid tissue to wounding identified using an in vitro model system. Eplasty 12:184-187. PMID:22536458.
- Boyce ST. In, A tribute to Richard G. Ham, Ph.D., 1932-2011; ed., WL McKeehan. In Vitro Cell and Developmental Biology 48(5):259-70. PMID:22580908
- Boyce ST, RK Rice, KC Lynch, AP Supp, VB Swope, RJ Kagan, and DM Supp. Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound Repair Regen 20(4):544-51. PMID:22672265.
- Sriwiriyanont P, KA Lynch, EA Maier, JM Hahn, DM Supp, and ST Boyce. 2012. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Exp Dermatol 21(10):783-785. PMID:23078401.
- Sriwiriyanont P, KA Lynch, KL McFarland, DM Supp, and ST Boyce. Characterization of hair follicle development in engineered skin substitutes. PLoS-ONE 8(6):e65664. doi:10.1371/journal.pone.0065664.
- Singer, AG, DH Ahrenholz, P Chang, RAF Clark, R Fey, P Fidler, W Garner, N Gibran, D Greenhalgh, S Honari, L Jones, R Kagan, J Kirby, J Leggett, N Meyer, C Reigart, K Richey, L Rosenberg, J Weber, B Wiggins, and ST Boyce. Burn wound healing outcomes. J Burn Care and Res 34(4):381-385. doi:10.197/BCR.0b01e31828cb249.
- Hahn, JK, K Glaser, KL McFarland, B Aronow, ST Boyce, and DM Supp. Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound Repair Regen 21:530-544. doi:10.1111/wrr.12060.
- Rieman MT, A Neeley, ST Boyce, WJ Kossenjans, PJ Durkee, JM Zembrodt, BK Puthoff, and RJ Kagan. Amish Burn Ointment (ABO) and burdock leaf dressings: assessments of antimicrobial & cytotoxic activities. J Burn Care Res 35(4):e217-e223. doi:10.1097/BCR.0b013e3182a23228.
- Sander EA, KA Lynch, and ST Boyce. Development of mechanical properties of engineered skin substitutes after grafting to athymic mice. J Biomech Eng 136(5):051008-1 – 051008-7. doi:10.1115/1.4026290.
- Lloyd CM, JA Besse, and ST Boyce. Controlled rate freezing to regulate the structure of collagen-glycosaminoglycan scaffolds in engineered skin substitutes. J Biomed Mater Res – part B; doi: 10.1002/jbm.b.33253, e-pub, 18Aug2014.
- Boyce ST, RL Zimmerman, and DM Supp. Tumorigenicity testing of cultured human melanocytes for restoration of skin color in engineered skin substitutes. Cell Transplantation 24:1423-1429. doi: 10.3727/096368914X683052. PMID:25199067.
- Zhou L, K Yang, M Xu, T Andl, SE Millar, S Boyce, and Y Zhang. Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity. FEBS J, 2016 Aug; 283(15):2823-35. doi: 10.1111/febs.13784. Epub, 11 Jul 2016.
- Supp DM, JM Hahn, KL McFarland, KA Combs, KSS Lee, B Inceoglu, D Wan, ST Boyce, and BD Hammock. Soluble epoxide hydrolase inhibition and topical epoxyeicosatrienoic acid treatment improve vascularization of engineered skin substitutes after transplantation to mice. Plast Reconstr Surg Global 4(12):e1151. doi: 10.1097/GOX.0000000000001151.
- Ventura SA, L Esfandiari, J Heikenfeld, ST Boyce, Y Park, and GB Kasting. 2017. Cortisol extraction through human skin by reverse iontophoresis. Bioelectrochemistry 114:54-60. PMID: 28081473. doi: 10.1016/j.bioelechem.2016.12.004. Epub 2016 Dec 28.
- Boyce ST, PS Simpson, MT Rieman, P Warner, KP Yakuboff, JK Bailey, JK Nelson, LA Fowler, and RJ Kagan. Randomized, paired-site, comparison of autologous engineered skin substitutes and split-thickness skin autograft for extensive, full-thickness burns. J Burn Care Res 38(2):61-70. PMID:27404165. doi: 10.1097/BCR.0000000000000401
- AJ Singer and ST Boyce. State of the science: burn wound healing, tissue engineering and regenerative medicine. J Burn Care Res 38(3):e605-e613. PMID:28328668. doi: 10.1097/BCR.0000000000000538.
- Supp DM and Boyce ST. Bioengineering of human skin substitutes. Chapter 47; In, “Biomedical Engineering Handbook”; editors, JP Fisher and AG Mikos; CRC Press, Inc.; Boca Raton, FL. pp 47-1 to 47-17.
- Powell HM and ST Boyce. Cultured skin substitutes. Chapter 12 in: “Biomaterials for Treating Skin Loss”; editors, D Orgill and C Blanco; Woodhead Publishing, Ltd; Abington, UK.
- Powell HM and ST Boyce. Tissue engineering of skin. In, “An introduction to biomaterials and their applications”; 2nd Edition; eds., Scott Guelcher, Jeffrey O. Hollinger. CRC Press, Inc; Boca Raton, FL.
- Boyce ST. Engineered skin substitutes: principles and practices. In, “Burns: Critical Care and Surgery”, second edition; editors, RL Zapata-Sirvent, CJ Jimenez-Castillo, J Besso; Ateproca Press; Caracas, Venezuela.
- Boyce ST. Translational research with engineered skin substitutes. In, “Burns: Critical Care and Surgery”, second edition; editors, RL Zapata-Sirvent, CJ Jimenez-Castillo, J Besso; Ateproca Press; Caracas, Venezuela.
- Boyce ST and DM Supp. Biologic skin substitutes. Chapter 11 in, “Tissue Engineering and Regenerative Medicine of Skin”; eds., MZ Albanna and JH Holmes IV; Elsevier Press; New York, New York, pp. 211-238. http://dx.doi.org/10.1016/B978-0-12-801654-1.00011-5.
- Boyce ST. US Patent 7,452,720B2, “Apparatus for preparing a biocompatible matrix”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. European Patent #1483373, “A surgical device for skin therapy or testing”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. US Patent 7,741,116, “A surgical device for skin therapy or testing”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. European Patent #1,483,365, “Apparatus for preparing a biocompatible matrix”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. US Patent 8,450,108, “A surgical device for skin therapy or testing”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. US Patent 8,765,468, “A surgical device for skin therapy or testing”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. US Patent 9,089,417, “A surgical device for skin therapy or testing”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. 2016. European Patent #2,075,330 B1 “A method of producing a cultured skin device”. Assignees: University of Cincinnati and Shriners Hospitals for Children.
- Boyce ST. 2016. European Patent #2,302,035 B1, “A method of producing a cultured skin device”. Assignees: University of Cincinnati and Shriners Hospitals for Children.